MaterniT21 Plus Screening

We are proud to offer our patients an exciting new testing option called MaterniT21 Plus. This prenatal screen is a new blood test offered through Sequenom Center for Molecular Medicine. This screen is designed to detect increased amounts of material from chromosome 21 (Down syndrome), chromosome 13 (trisomy 13) and chromosome 18 (trisomy 18) and requires only a maternal blood sample after 10 weeks of gestation. At this time MaterniT21 Plus screening is available to patients meeting one or more of the following criteria:

  • Advanced maternal age (35 years or older at the time of delivery)
  • Family history
  • Abnormal prenatal ultrasound findings
  • Increased risk based on screening results

The benefit of this screen is the high detection rates and low false-positive rates for these chromosome abnormalities with no risk to the pregnancy.

  • 99.1% detection for Down syndrome
  • 99.9% detection for trisomy 18
  • 91.7% detection for trisomy 13

This screen is not currently available to low-risk patients. This screen does not replace first trimester screening, but it is instead used in conjunction with first trimester screening and other prenatal screens to help better determine which patients would benefit from invasive prenatal diagnosis (i.e. chorionic villus sampling or amniocentesis). Genetic counseling is required prior to MaterniT21 Plus Screening to ensure adequate discussion of a patient's available testing options in terms of benefits, risks and limitations as well as to obtain appropriate written informed consent.

The out-of-pocket cost for testing depends upon a patient's insurance and will be discussed further during the genetic counseling session. The test results are typically available in 8-10 business days after the patient's blood is drawn.

More information can be found on Sequenom's website:

To schedule an appointment for a genetic consultation with one of our ABGC board certified or board eligible genetic counselors at one of our convenient locations, please call (845) 483-0500.


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© 2019 Keith Lescale, M.D., F.A.C.O.G.